Experiments on the Radioprotective Action of Dimethyl Sulphoxide

C. van der Meer Medical Biological Laboratory of the National Defence Research Organization TNO, Rijswijk (Z.H.), The Netherlands

P.W. Valkenburg Medical Biological Laboratory of the National Defence Research Organization TNO, Rijswijk (Z.H.), The Netherlands

M. Remmelts Medical Biological Laboratory of the National Defence Research Organization TNO, Rijswijk (Z.H.), The Netherlands

Summary

The radioprotective action of dimethyl sulphoxide against a lethal dose of x-rays was investigated in two strains of mice. The protection is somewhat better in CBA/Rij than in C57BL/Rij mice. At protective doses a marked fall in the oxygen tension in the spleen is found. This effect is greater in the CBA/Rij than in the C57BL/Rij mice.

The intraperitoneal injection of dimethyl sulphoxide causes an abrupt rise in blood pressure lasting only a few minutes.

The mechanism of action of dimethyl sulphoxide in the mouse is discussed.

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Experiments on the Radioprotective Action of Dimethyl Sulphoxide

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Experiments on the Radioprotective Action of Dimethyl Sulphoxide

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