Variations in the Blood-content of ⁹⁰Sr/⁹⁰Y of Mice Injected after a 200 r Whole-body X-ray Dose

Summary

Male albino mice were given a whole-body roentgen dose of 200 r and were then intraperitoneally injected at various intervals with 4 μc ⁹⁰Sr. The animals were killed at various times after the injections, and the ⁹⁰Sr/⁹⁰Y-content of whole blood was estimated. Non-irradiated mice were used as controls.

The values of ⁹⁰Sr obtained agree with a theoretical equation expressing the overall state of isotope in blood after an intraperitoneal injection. The constants for the two interacting processes, r for inflow and q for outflow of isotope in the blood, are increased in irradiated animals as compared with controls. This indicates an injury to the transport routes of injected isotope to and from the blood system, induced by a 200 r whole-body dose. This injurious effect of x-rays can be demonstrated as early as 5 min after the roentgen treatment.