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Summary
Primary roots of Vicia faba seedlings were irradiated with gamma-, x- and beta-rays in a sulphoguanidine solution. Analysis of anaphase aberrations showed that the breakage-reunion index (which is the number of anaphase fragments per bridges) in the middle of the first mitosis after irradiation, is constant, and at low doses is independent of the intensity and quality of ionizing radiation.
The breakage-reunion index indicates that after irradiation in the presence of sulphoguanidine, twice as many breaks enter into reunion as in distilled water. This cytological effect of the sulphoguanidine was suspended by p-aminobenzoic acid, folic acid, arginine and guanine, as well as by 2,4-dinitrophenol and chloramphenicol. Therefore, the sulphoguanidine effect seems to be connected with the chromosomal histone and DNA-synthesis. p-nitrobenzoic acid has the same effect as the sulphoguanidine. The cytological effect of these compounds was linked with a radiosensitizing effect, manifested in root-growth inhibition.