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Summary
Male rats of 200 g body-weight were exposed to whole-body x-irradiation with doses from 50 to 1200 R and urine was collected for the first 24 hours after. Chromatographic separation of de-salted urine samples allowed quantitative spectrophotometric determinations of thymidine, deoxyuridine, pseudouridine, and uracil to be made.
A marked increase in thymidine excretion is found after irradiation, from 40 to 1800 µg per 24 hours. The thymidine excretion increases with dose in the range investigated. Deoxyuridine gives a similar but smaller and less regular response to irradiation.
The excretion of pseudouridine and uracil shows no significant changes with irradiation. The thymine excretion values are so low normally and change so little with irradiation that no acceptable analytical results were obtained for this substance.