Inactivation of the Phage of Staphylococcus Aureus with Acridine Orange

Summary

The action of the photodynamically active radiomimetic acridine orange on several phages of Staphylococcus of known morphology, serological type, phage type and the base composition in DNA has been studied. For these phages, the inactivation rate has been investigated, both at photodynamic inactivation with 10 μg/ml. AO and at inactivation in the dark with a tenfold concentration of the dye. Taxonomically related bacteriophages were inactivated with AO to approximately the same extent, whereas no correlation has been found between the rate of inactivation in the dark and the serological groups of Staphylococcus phages.