Accumulation of Fructose-1,6-diphosphate in X-irradiated Rat Thymocytes

Summary

Accumulation of fructose-1,6-diphosphate in x-irradiated rat thymocytes was shown to be dependent on x-ray doses ranging from 300 R to 32 kR. Inhibition of cell respiration was also dose-dependent, and oxygen consumption was decreased with increasing doses. There was a marked stimulation of aerobic glycolysis in the dose range up to 8 kR. It is suggested that the accumulation of fructose-1,6-diphosphate was a very early effect of ionizing radiation on the cell and was involved in the decline of ATP.