Survival of Synchronized V79 Cells Treated with X-rays and Cordycepin

Summary

The survival of V79 Chinese hamster lung cells exposed to X-irradiation is reduced by co-treatment with cordycepin (3′-deoxyadenosine). This reduction is manifested principally by a decrease in the D₀ of the X-ray survival curve from 199 rad in untreated cells to 106 rad in cordycepin-treated cells. Reduced survival is seen throughout the life-cycle when synchronized cell populations are exposed to both agents with cells in mid-S being especially sensitive.