Stage-sensitivity and Dose-response Study after γ-irradiation of Mouse Primary Spermatocytes

Summary

The sensitivity pattern for X-ray-induced chromatid aberrations was analysed in primary spermatocytes irradiated at 1 to 11 days before diakinesis-metaphase I of meiosis. Using a dose of 300 R (60 R/min) of γ-rays zygotene (day 9) was found to be the most sensitive and leptotene (day 11) the most insensitive stage. The dose-response to γ-ray-induced aberrations was evaluated in cells irradiated at zygotene. Both the yields of rearrangements as well as the yields of fragments gave a best fit to a quadratic model.