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International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Volume 36, 1979 - Issue 3
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Original Article

Effect of Ionizing Radiations on the Life Span of Non-transformed Human Fibroblasts

Genèvieve Laublin Centre Antoine-Lacassagne, 36 Avenue de la Voie Romaine, 06000, Nice, France
,
Patrick J. Deschavanne Laboratoire de Radiobiologie Cellulaire, Institut de Radiobiologie Clinique, Institut Gustave-Roussy, 94800, Villejuif, France
&
Edmond P. Malaise Institut Carnoy, Unité de Cytogénétique, 4 Place Croix du Sud, 1348, Louvain-la-Neuve, Belgique
Pages 281-288 | Received 04 Oct 1978, Accepted 15 Jan 1979, Published online: 03 Jul 2009
 
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Summary

We studied in vitro the influence of ionizing radiations on the life span of non-transformed HF 19 human fibroblasts. The life span of surviving clones was found to be reduced when the cells had received two or three doses of 6 Gy separated by an interval of 15 doublings. In addition, this reduction in life span was greater when the cells were older at the time of irradiation.

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