Advanced search
Publication Cover
International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Volume 37, 1980 - Issue 5
Journal homepage
2
Views
2
CrossRef citations to date
0
Altmetric
Original Article

Modification of the Action of Misonidazole

II. Effect of TAN on Radiosensitization

K.A. Skov Medical Biophysics Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., V5Z IL3
,
B. Palcic Medical Biophysics Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., V5Z IL3
,
I.E. Harrison Medical Biophysics Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., V5Z IL3
&
L.D. Skarsgard Medical Biophysics Unit, British Columbia Cancer Research Centre, 601 West 10th Avenue, Vancouver, B.C., V5Z IL3
Pages 613-620 | Received 22 Aug 1979, Accepted 03 Dec 1979, Published online: 03 Jul 2009
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Summary

Radiosensitization by misonidazole of hypoxic mammalian cells in dilute suspension is modified by the presence of the stable free radical, TAN. The dose modifying factor (DMF) of 15 mM misonidazole is 2·4 for cell inactivation, and 3·5 for the production of single-strand breaks in DNA. The presence of TAN decreases these values to 1·5 and 1·75 respectively. Possible explanations for these observations are discussed. The DMF of misonidazole for cells in pellet is not affected by TAN.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.