Radioimmunoassay of 7,8-dihydro-8-oxoadenine (8-hydroxyadenine)

Gregory J. West Department of Radiology, School of Medicine M-027, University of California, San Diego, La Jolla, California, 92093

Irene W.-L. West Department of Radiology, School of Medicine M-027, University of California, San Diego, La Jolla, California, 92093

John F. Ward Department of Radiology, School of Medicine M-027, University of California, San Diego, La Jolla, California, 92093

Summary

A sensitive and specific radioimmunoassay for 8-hydroxyadenine has been developed. As little as 4 × 10⁻¹⁴ moles of 8-hydroxyadenine can be detected. Unmodified DNA cross-reacts only at concentrations greater than 20 μg/ml. 8-hydroxyadenine can be detected in γ-irradiated DNA at doses less than 10 Gy. The assay requires only mild chemical treatment and many samples can be quickly and easily handled.

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Radioimmunoassay of 7,8-dihydro-8-oxoadenine (8-hydroxyadenine)

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Radioimmunoassay of 7,8-dihydro-8-oxoadenine (8-hydroxyadenine)

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