Hyperthermia in a Differentiating Murine Erythroleukaemia Cell Line: II. Effect of Heat on Haem Induction by Radiation

G.P. Raaphorst Medical Biophysics Branch, Whiteshell Nuclear Research Establishment, Atomic Energy of Canada Limited, Pinawa, Manitoba, Canada, R0E 1L0

E.I. Azzam Medical Biophysics Branch, Whiteshell Nuclear Research Establishment, Atomic Energy of Canada Limited, Pinawa, Manitoba, Canada, R0E 1L0

J. Borsa Medical Biophysics Branch, Whiteshell Nuclear Research Establishment, Atomic Energy of Canada Limited, Pinawa, Manitoba, Canada, R0E 1L0

M. Einspenner Medical Biophysics Branch, Whiteshell Nuclear Research Establishment, Atomic Energy of Canada Limited, Pinawa, Manitoba, Canada, R0E 1L0

J. Vadasz Medical Biophysics Branch, Whiteshell Nuclear Research Establishment, Atomic Energy of Canada Limited, Pinawa, Manitoba, Canada, R0E 1L0

Summary

Friend erythroleukaemia cells (FELC) were induced to a haem-producing state by X-rays. The percentage of haem positive cells was maximum for doses between 10 and 15 Gy. Heat treatment at 42·0°C or 45·0°C during or after irradiation inhibited haem induction whereas heating before irradiation enhanced it. Incubation at 37°C between heating and irradiation resulted in a decline in induction levels, indicating repair of heat damage that interacts with X-ray damage. Incubation at 37°C between irradiation and heating did not result in changed haem induction levels, indicating a lack of repair of radiation damage that could interact with subsequent damage produced by heating.

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Hyperthermia in a Differentiating Murine Erythroleukaemia Cell Line: II. Effect of Heat on Haem Induction by Radiation

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Hyperthermia in a Differentiating Murine Erythroleukaemia Cell Line: II. Effect of Heat on Haem Induction by Radiation

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