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International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine Volume 51, 1987 - Issue 4
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Original Article

The Inhibitory Effect of Succinate on Radiation-enhanced Mitochondrial Lipid Peroxidation

Eva Ronai Federic Joliot Curie National Research Institute for Radiobiology and Radiohygiene, H-1121, Budapest, Hungary
,
Laszlo Tretter Second Institute of Biochemistry, Semmelweis University Medical School, H-1444, Budapest, Hungary
,
Gyorgy Szabados Federic Joliot Curie National Research Institute for Radiobiology and Radiohygiene, H-1121, Budapest, Hungary
&
Istvan Horvath Second Institute of Biochemistry, Semmelweis University Medical School, H-1444, Budapest, Hungary
Pages 611-617 | Received 25 Jul 1986, Accepted 27 Oct 1986, Published online: 03 Jul 2009
 
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Summary

The degree of mitochondrial ADP/Fe/NADPH-induced lipid peroxidation was increased up to the fourth day after 9·0 Gy whole body γ-irradiation. The lipid peroxidation inhibiting effect of succinate added to isolated mitochondria was diminished as a consequence of irradiation. The succinate, administered in vivo prior to irradiation, decreased the amount of malondialdehyde production and protected the succinate dehydrogenase enzyme against inactivation. The mean survival of succinate-pretreated animals was much longer than that of controls. The role of mitochondrial lipid peroxidation in the pathogenesis of radiation injury is discussed.

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