Histopathological Changes in the Ovary Following Acute and Chronic Low-level Tritium Exposure to Mice in Vivo

Summary

Swiss albino mice were exposed to various doses of tritiated water, either through intraperitoneal injection (acute) or orally (chronic) for various lengths of time. The ovaries were examined for qualitative histopathological and quantitative changes in the number of oocytes. All experimental groups displayed varying degrees of dose dependent radiolesions. It was found that chronic irradiation was more damaging than multiple weekly injection, which in turn was more damaging than a single injection. Also, radiosensitivity varied with the age of the mice.

• tritiated water
• ovary
• histopathology