Generation of Radical Anions from Metronidazole, Misonidazole and Azathioprine by Photoreduction in the Presence of EDTA

Douglas E. Moore Department of Pharmacy, The University of Sydney, Sydney, 2006, Australia

Colin F. Chignell Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle ParkNC, 27709, U.S.A.

Robert H. Sik Department of Chemistry, Duke University, Durham, NC, 27707, U.S.A.

Ann G. Motten Department of Pharmacy, The University of Sydney, Sydney, 2006, Australia

Summary

Ultraviolet irradiation of the nitroimidazole derivatives metronidazole, misonidazole, azathioprine and 1-methyl-4-nitroimidazole in aqueous solution with various reductants produced the respective nitro radical anions, as detected by electron spin resonance spectroscopy. The most effective reductant, yielding high concentrations of the radical anions, was EDTA at pH 10. NADH, NADPH, formaldehyde glutathione and methanol were also tested but were less efficient as reductants.

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Generation of Radical Anions from Metronidazole, Misonidazole and Azathioprine by Photoreduction in the Presence of EDTA

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Generation of Radical Anions from Metronidazole, Misonidazole and Azathioprine by Photoreduction in the Presence of EDTA

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