Effective Chelation Therapy after Incorporation of Neptunium-239 in Rats

Summary

It was demonstrated in rats that it is possible to reduce the retention of ²³⁹Np in all body tissues by an early combined treatment with small doses of DTPA and DFOA. The content of ²³⁹Np can be decreased in soft tissues even if treatment is delayed. Promptly administered LICAM(C) proved more effective than the above chelate combination in reducing ²³⁹Np retention in the bones but increased that in the muscles and especially in the kidneys. This side effect of LICAM(C) could be partly prevented by simultaneous treatment with DTPA.

• chelation therapy
• neptunium