The Importance of NPSH on the Radiosensitizing Effect of Oxygen in Chinese Hamster V-79 Cells

Summary

The radiosensitivity of Chinese hamster V-79-171B fibroblasts increased more rapidly with increasing partial pressure of oxygen when the cell cultures had low endogenous levels of non-protein sulphydryl (NPSH), about 5 µmol per cell compared with about 15 µmol per cell. There was a good correlation between initial NPSH content and sensitization by oxygen concentrations between 0·06 and 0·7 per cent.

• oxygen
• non-protein sulphydryl
• V-79
• fibroblasts
• K-values