Cellular Glutathione Content and K Values

Summary

The K values for two cell strains with differing intrinsic GSH concentrations have been measured with the yield of DNA breaks as end-point of the radiation effect. The K value of the strain with reduced GSH content was decreased (1·59 µm O₂) in comparison to the K value (3·01 µm O₂) for the strain with a normal GSH content. The significance of the observation is discussed in relation to competition models. All variants of the competition model agree in predicting a reduction of K, if GSH is reduced.

• glutathione
• oxygen effect
• K value