Effect of Cellular Glutathione Content on the Induction of DNA Double Strand Breaks by 25 MeV Electrons

D. Frankenberg Institut für Biophysikalische Strahlenforschung der Gesellschaft für Strahlenund Umweltforschung mbH, Paul-Ehrlich-Str. 20, D-6000, Frankfurt, 70, F.R. Germany

M. Kistler Institut für Strahlenbiologie der Gesellschaft für Strahlen- und Umweltforschung mbH, Ingolstädter Landsr. 1, D-8042, Neuherberg, 70, F.R. Germany

F. Eckardt-Schupp Institut für Biophysikalische Strahlenforschung der Gesellschaft für Strahlenund Umweltforschung mbH, Paul-Ehrlich-Str. 20, D-6000, Frankfurt, 70, F.R. Germany

Summary

The effect of endogenous glutathione (GSH) on the induction of DNA double strand breaks (dsb) by 25 MeV electrons was investigated using stationary haploid yeast cells defective in γ-glutamyl-cysteine-synthetase (gsh 1) containing less than 5 per cent of the normal GSH content. In gsh 1 cells the induction of dsb is increased by a factor of 1·5 under oxic and 1·8 under anoxic irradiation conditions: whereas the oxygen enhancement ratio was only slightly decreased (1·9) compared to wild-type cells (2·4).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Effect of Cellular Glutathione Content on the Induction of DNA Double Strand Breaks by 25 MeV Electrons

Information for

Open access

Opportunities

Help and information

Effect of Cellular Glutathione Content on the Induction of DNA Double Strand Breaks by 25 MeV Electrons

Summary

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature