Rapid Communication

Stochastic Model of Free Radical Yields in Oriented DNA Exposed to Densely Ionizing Radiation at 77K

J.H. Miller Pacific Northwest Laboratory, PO Box 999, Richland, Washington, 99352, U.S.A.

W.E. Wilson Armed Forces Radiobiology Research Institute, Bethesda, Maryland, 20814-5145, U.S.A.

C.E. Swenberg Uniformed Services University of the Health Sciences, Bethesda, Maryland, U.S.A.

L.S. Myers Jr Concordia University, Montreal, Quebec, Canada

D.E. Charlton Pacific Northwest Laboratory, PO Box 999, Richland, Washington, 99352, U.S.A.

Summary

Monte Carlo simulation techniques were used to calculate the probability that thymine radical anions (T), formed by the slowing-down of high-energy protons in oriented DNA, will undergo a secondary proōtonation reaction. By assuming a large asymmetry in the thermal conductivity of oriented DNA fibres we predict a significant enhancement of protonation of T when the proton flux is incident on the sample parallel to the orientation of the DNA. These results are in qualitative agreement with experimental data on the production of TH· radicals when oriented DNA is exposed to fast neutrons.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Rapid Communication

Stochastic Model of Free Radical Yields in Oriented DNA Exposed to Densely Ionizing Radiation at 77K

Information for

Open access

Opportunities

Help and information

Rapid Communication

Stochastic Model of Free Radical Yields in Oriented DNA Exposed to Densely Ionizing Radiation at 77K

Summary

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature