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International Journal of Radiation Biology Volume 53, 1988 - Issue 6
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Original Article

Induction of Sister Chromatid Exchanges (SCE) in G0 Lymphocytes by Plutonium-238 α-particles

S.Z. Aghamohammadi Medical Research Council, Radiobiology Unit, Chilton, Didcot, OX11 0RD, U.K.
,
D.T. Goodhead Medical Research Council, Radiobiology Unit, Chilton, Didcot, OX11 0RD, U.K.
&
J.R.K. Savage Medical Research Council, Radiobiology Unit, Chilton, Didcot, OX11 0RD, U.K.
Pages 909-915 | Received 06 Nov 1987, Accepted 25 Jan 1988, Published online: 03 Jul 2009
 
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Summary

Irradiation of human G0 lymphocytes with plutonium-238 α-particles and X-rays was performed to investigate the production of sister chromatid exchanges (SCE). Alpha-particles produce a significant increase in SCE and this elevation is more significant when separated lymphocytes are irradiated. X-ray irradiation did not induce any significant increase in SCE. Therefore the relative biological effectiveness (RBE) for the induction of SCE by α-particles in this system is undefined and effectively infinite.

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