The Induction of Micronuclei in Human Lymphocytes by in Vitro Irradiation with Alpha Particles from Plutonium-239

A. Bilbao Departamento de Biologie Celular e Histología, Facultad de Medicina, Universidad del País Vasco, Leioa (Vizcaya), Spain

J.S. Prosser National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 0RQ, U.K.

A.A. Edwards Departamento de Biologie Celular e Histología, Facultad de Medicina, Universidad del País Vasco, Leioa (Vizcaya), Spain

J.C. Moody National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 0RQ, U.K.

D.C. Lloyd Departamento de Biologie Celular e Histología, Facultad de Medicina, Universidad del País Vasco, Leioa (Vizcaya), Spain

Summary

Human peripheral blood lymphocytes were irradiated for 24 h in vitro with plutonium-239 citrate. The dose response for micronucleus induction using the cytochalasin B blocking technique fitted well to a linear relationship. Comparison with published data from the same laboratory using X-irradiation, indicated an RBE of 3·6 for alpha particles at low doses.

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The Induction of Micronuclei in Human Lymphocytes by in Vitro Irradiation with Alpha Particles from Plutonium-239

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The Induction of Micronuclei in Human Lymphocytes by in Vitro Irradiation with Alpha Particles from Plutonium-239

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