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International Journal of Radiation Biology Volume 57, 1990 - Issue 5
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Original Article

Rapid communication

Radiation Sensitization by an Iodine-labelled DNA Ligand

R.F. Martin Molecular Sciences Group, Peter MacCallum Cancer Institute, 481 Little Lonsdale Street, Melbourne, Victoria, 3000, Australia
,
V. Murray Department of Pathology, University of Melbourne, Australia
,
G. D'Cunha Department of Organic Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia
,
M. Pardee Molecular Sciences Group, Peter MacCallum Cancer Institute, 481 Little Lonsdale Street, Melbourne, Victoria, 3000, Australia
,
E. Kampouris Department of Pathology, University of Melbourne, Australia
,
A. Haigh Department of Organic Chemistry, University of Melbourne, Parkville, Victoria, 3052, Australia
,
D.P. Kelly Molecular Sciences Group, Peter MacCallum Cancer Institute, 481 Little Lonsdale Street, Melbourne, Victoria, 3000, Australia
&
G.S. Hodgson Department of Pathology, University of Melbourne, Australia
 show all
Pages 939-946 | Received 15 Sep 1989, Accepted 29 Nov 1989, Published online: 03 Jul 2009
 
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Summary

An iodinated DNA ligand, iodoHoechst 33258, which binds in the minor groove of DNA, enhances DNA strand breakage and cell killing by UV-A irradiation. The sites of UV-induced strand breaks reflect the known sequence specificity of the ligand.

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