Post-irradiation Treatment with OK432 Can Prevent Radiation-induced Bone Marrow Death

A. Kurishita Radiation Biology Center, Kyoto University, Kyoto, 606, Japan

H. Katoh Department of Radiation Research, Tohoku University School of Medicine, Sendai, 980, Japan

Y. Uehara Department of Analytical Chemistry, Kyoto Pharmaceutical University, Kyoto, 607, Japan

A. Uchida Radiation Biology Center, Kyoto University, Kyoto, 606, Japan

Y. Mizutani Department of Radiation Research, Tohoku University School of Medicine, Sendai, 980, Japan

T. Ono Department of Analytical Chemistry, Kyoto Pharmaceutical University, Kyoto, 607, Japan

S. Hirose Radiation Biology Center, Kyoto University, Kyoto, 606, Japan

S. Okada Department of Radiation Research, Tohoku University School of Medicine, Sendai, 980, Japan

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Summary

The radioprotective effect of OK432, a Streptocuccus haemolyticus preparation, on bone marrow death was examined in mice. The LD₅₀ value was increased from 7·55 Gy in controls to 8·45 Gy in mice treated once with OK432 immediately after irradiation. Multiple administrations of the agent further elevated the LD₅₀ value to 9·56 Gy. The radioprotective effect was also apparent when multiple treatments were commenced as late as 72 h after irradiation.

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Post-irradiation Treatment with OK432 Can Prevent Radiation-induced Bone Marrow Death

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Post-irradiation Treatment with OK432 Can Prevent Radiation-induced Bone Marrow Death

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