Radioprotective Effects of Prostaglandins for Chromosomal Aberrations and Cell Killing in V79 Chinese Hamster Cells Grown as Spheroids in Vitro and for Mouse Spermatogonial Stem Cells and Bone Marrow Cells in Vivo

K. Sankaranarayanan MGC, Department of Radiation Genetics and Chemical Mutagenesis, University of Leiden, Sylvius Laboratories, Wassenaarseweg 72, 2333 Al, Leiden, The Netherlands

A.V. Duyn-Goedhart Department of Cell Biology, University of Utrecht Medical School, 3508 TD, Utrecht, The Netherlands

D.G. De Rooij MGC, Department of Radiation Genetics and Chemical Mutagenesis, University of Leiden, Sylvius Laboratories, Wassenaarseweg 72, 2333 Al, Leiden, The Netherlands

P.P.W. Van Buul Department of Cell Biology, University of Utrecht Medical School, 3508 TD, Utrecht, The Netherlands

Abstract

The radioprotective effects of prostaglandins (PGE₂, PGE₁ and its analogue misoprostol (MP) were investigated in cultures of V79 Chinese hamster (CHO) cells grown as spheroids and as monolayers, CHO cells grown as monolayers, and in bone marrow polychromatic erythrocytes and spermatogonial stem cells in mouse. The X-ray doses were 0·75 Gy (hamster cells) and 5, 8 and 10 Gy (mouse experiments).

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Radioprotective Effects of Prostaglandins for Chromosomal Aberrations and Cell Killing in V79 Chinese Hamster Cells Grown as Spheroids in Vitro and for Mouse Spermatogonial Stem Cells and Bone Marrow Cells in Vivo

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Radioprotective Effects of Prostaglandins for Chromosomal Aberrations and Cell Killing in V79 Chinese Hamster Cells Grown as Spheroids in Vitro and for Mouse Spermatogonial Stem Cells and Bone Marrow Cells in Vivo

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