Repair of UV-induced Pyrimidine(6-4)Pyrimidone Photoproducts is Selectively Inhibited in Transcriptionally Active Genes after Heat Treatment of Human Fibroblasts

R.J. Sakkers MGC-Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands

A.R. Filon J. A. Cohen Institute, Interuniversity Research Institute for Radiopathology and Radiation Protection, Leiden, The Netherlands

H.H. Kampinga Department of Radiobiology, University of Groningen, Bloemsingel 1, 9713 BZ, Groningen, The Netherlands

A.W.T. Konings MGC-Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, Wassenaarseweg 72, 2333 AL, Leiden, The Netherlands

L.H.F. Mullenders J. A. Cohen Institute, Interuniversity Research Institute for Radiopathology and Radiation Protection, Leiden, The Netherlands

Abstract

In normal human fibroblasts, repair of (6-4)PP in the active adenosine deaminase (ADA) gene occurs with similar rate in the transcribed and non-transcribed strand of the ADA gene, and removal of (6-4)PP from the active ADA gene is faster than from the inactive X-chromosomal 754 locus. Heat shock decreased the rate of repair of the active ADA gene down to the level of inactive genes, whereas the rate of repair of the inactive 754 locus was not affected.

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Repair of UV-induced Pyrimidine(6-4)Pyrimidone Photoproducts is Selectively Inhibited in Transcriptionally Active Genes after Heat Treatment of Human Fibroblasts

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Repair of UV-induced Pyrimidine(6-4)Pyrimidone Photoproducts is Selectively Inhibited in Transcriptionally Active Genes after Heat Treatment of Human Fibroblasts

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