Abstract
Substantial progress has been made in the pharmacotherapy of withdrawal syndromes and organic complications of alcohol and drug abuse. Diazepam loading (alcohol withdrawal), phenobarbital loading (barbituate withdrawal) and diazepam tapering (benzodiazepine discontinuation) have considerably simplified treatment of withdrawal syndromes and have enhanced efficacy. Propylthiouracil shows considerable promise in the out-patient treatment of alcoholic liver disease. New medications, particularly those modifying serotonergic function, have efficacy in decreasing alcohol consumption and show considerable therapeutic potential. Human pharmacology and pharmacotherapy should be a central part of training programmes in the field in order that further advances can be made.