Abstract
The synthetic versatility of 3-[p-(hydrazinocarbonyl)]phenylsydnone is demonstrated in the syntheses of various heterocyclic compounds. For example, pyrazoles, fused pyranopyrazoles, 1,3,4-thiadiazoles, 1,3,4-oxadiazoles and 1,2,4-triazoles can be built on the phenyl ring of this 3-phenyl sydnone. The phenylsydnones prepared herein were characterized spectroscopically and subjected to antibacterial and antifungal screening. The compounds demonstrated high fungicidal activities. 3-[p-(hydrazinocarbonyl)]phenylsydnone has proven to be a versatile precursor for the synthesis of various related derivatives and may be used further in preparing various pharmaceutical and agricultural compounds.
Acknowledgments
The authors thank the University Sophisticated Instrumentation Centre, Karnatak University, Dharwad for IR and NMR data. They are also thankful to Prof. S.N. Pattan of K.L.E.' s College of Pharmacy, Belgaum, Karnataka for their kind cooperation and useful suggestions in carrying out the pharmacological activities.