A new flavonolignan from milk thistle (Silybum marianum)

Abstract

A new flavonolignan, sonyamandin (1), along with other known compounds was isolated from the aerial parts and seeds extracts of Silybum marianum (milk thistle) collected from Jordan. The known ones are ursolic acid (2), oleanolic acid (3), maslinic acid (4), oleic acid (5), β-sitosterol (6), β-, sitosteryl glucoside (7), apigenin (8), kaempferol-3-O-rhamnoside (9), apigenin-7-O-β-D-glycoside (10), isosylibin A (11), isosylibin B (12), and silybin B (13). The absolute stereochemistry of 1 was confirmed by 2D NMR and CD analysis.

Keywords:

• Silybum marianum
• flavonolignan
• sonyamandin
• hepatoprotective activity
• stereochemistry
• CD

Acknowledgments

The authors thank Prof. Atia-tul Wahab from the International Center for Chemical and Biological Sciences, University of Karachi, Pakistan for performing CD and UV analysis, and Prof. Mustafa Al Abadelah from the Chemistry Department, University of Jordan, Jordan for his assistance in the interpretation of CD data.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.