cAMP-dependent signal pathways in unicellular eukaryotes

Abstract

The review summarizes current data about mechanisms of signal transduction with participation of cAMP (cyclic adenosine monophosphate) and elements of the complex cAMP–protein kinase A (PKA) signal pathway in unicellular eukaryotes. Conceptions of evolutionary origin of eukaryotic signal transduction systems are developed.

Keywords::

• Unicellular Eukaryotes
• Intracellular Signaling
• cAMP
• Heterotrimeric G proteins
• Proliferation
• Differentiation
• Chemotaxis
• PKA
• MAPK

Acknowledgments

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.