Cloning and Identification of a Novel Human Gene PDLIM5, a Homolog of AD-associated Neuronal Thread Protein (AD7c-NTP)

Maoqing Wu† State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, China

Yao Li† State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, China

Chaoneng Ji State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, China

Jian Xu State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, China

Huarui Zheng State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, China

Xianqiong Zou State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, China

Shaohua Gu State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, China

Yi Lou State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, China

Yi Xie State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, China

Yumin Mao State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, ChinaCorrespondence[email protected]

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Abstract

A novel human gene cDNA was successfully cloned from the human fetal brain cDNA library constructed by our lab, and this gene was termed PDLIM5 after acquiring the agreement of HUGO. BLASTX searching revealed that the hypothetical protein is a homolog of AD-associated neuronal thread protein (AD7c-NTP), which is over-expressed in Alzheimer disease (AD) beginning early in the course of disease, and over-expression of the AD7c-NTP gene would cause neuritic sprouting and cell death. SMART analysis showed that both our predicted protein and AD7c-NTP comprise BCL domain (only contains BH1 and BH2 regions). RT-PCR experiment revealed that the expression level of PDLIM5 in brain, skeletal muscle, prostate, colon and leukocyte is obviously higher than that in other tissues.

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Cloning and Identification of a Novel Human Gene PDLIM5, a Homolog of AD-associated Neuronal Thread Protein (AD7c-NTP)

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Cloning and Identification of a Novel Human Gene PDLIM5, a Homolog of AD-associated Neuronal Thread Protein (AD7c-NTP)

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