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DNA Sequence Volume 15, 2004 - Issue 2
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Original Article

Molecular Cloning and Characterization of SGT1.2, a Novel Splice Variant of Homo sapiens SGT1

Xianqiong Zou* School of Resource Processing and Bio-engineering, Central South University, 410083, Changsha, P. R. China
,
Chaoneng Ji* State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. China
,
Liu Wang State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. China
,
Maoqing Wu State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. China
,
Huarui Zheng State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. China
,
Jian Xu State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. China
,
Feng Jin State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. China
,
Shaohua Gu State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. China
,
Kang Ying State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. China
,
Yi Xie† State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. China
&
Yumin Mao State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, 200433, Shanghai, P. R. ChinaCorrespondence[email protected]
 show all
Pages 140-143 | Received 30 May 2003, Published online: 11 Jul 2009
 
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Abstract

SGT1.2, a novel splice variant of Homo sapiens SGT1 was isolated from a human fetal brain cDNA library. This cDNA is 1404 bp and contains an open reading frame from 68 to 1165 encoding a putative protein of 365 amino acids (SGT1.2) that share 90% identities to Homo sapiens SGT1, suppressor of G2 allele of SKP1 at protein level. RPS-BLAST searching revealed that SGT1.2 have a TPR domain, a p23 domain, a SGS domain and a CS domain. According to the search of the human genome database, SGT1.2 was mapped to human chromosome 13q14.13. Reversed transcription-polymerase chain reaction analysis indicated that it widely expressed in human adult tissues.

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