Diffuse Large B-cell Lymphoma with Infiltration-Associated Peripheral Neuropathy and Paraneoplastic Myopathy with a Prolonged Course Over Seven Years

M. Fiegl Department of Internal Medicine, Division of Clinical Hematology and Oncology, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria

A. Muigg Department of Neurology, University of Innsbruck, Innsbruck, Austria

A. Smekal Department of Radiology II, University of Innsbruck, Innsbruck, Austria

J. Krugmann Institute of Pathology, University of Innsbruck, Innsbruck, Austria

S. Dirnhofer Institute of Pathology, University of Basel, Basel, Switzerland

R. Greil Department of Internal Medicine, Division of Clinical Hematology and Oncology, University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria

Abstract

Rarely lymphoproliferative disorders (LPD) may be associated with peripheral neuropathy, based on different mechanisms of pathogenesis. Here, we report a case of a primary extranodal diffuse large B-cell lymphoma which showed a prolonged course with several recurrences manifesting as neuropathies, and long term remissions achieved by chemotherapy and involved field radiation. Repeated pathohistologic evaluations showed spread of lymphoma growth predominantly along nerve structures, suggesting neurotropism of the lymphoma cells.

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Diffuse Large B-cell Lymphoma with Infiltration-Associated Peripheral Neuropathy and Paraneoplastic Myopathy with a Prolonged Course Over Seven Years

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Diffuse Large B-cell Lymphoma with Infiltration-Associated Peripheral Neuropathy and Paraneoplastic Myopathy with a Prolonged Course Over Seven Years

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