New Candidate Virus in Association with Hodgkin's Disease

D. Benharroch Department of Pathology, Soroka University Medical Center, P.O. Box 151, Beer-Sheva 84101, Israel

Y. Shemer-Avni Department of Virology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel

A. Levy Department of Epidemiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Y.Y. Myint Department of Pathology, Soroka University Medical Center, P.O. Box 151, Beer-Sheva 84101, Israel

S. Ariad Department of Oncology, Soroka University Medical Center, Beer-Sheva, Israel

B. Rager Departments of Immunology and Microbiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

M. Sacks Department of Pathology, Soroka University Medical Center, P.O. Box 151, Beer-Sheva 84101, Israel

J. Gopas Department of Pathology, Soroka University Medical Center, P.O. Box 151, Beer-Sheva 84101, Israel

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Abstract

Epidemiologic and molecular investigations of Hodgkin's disease (HD) suggest a strong infectious association. The Epstein-Barr virus (EBV), together with its viral proteins, is expressed in Hodgkin-Reed-Sternberg (HRS) cells in the lymph nodes involved by HD. EBV is more likely to be related to childhood and older adult cases of HD and is much less frequently expressed in young adult HD patients, the group most expected to be associated with an infectious agent. In addition, the "hit and run" theory of EBV infection remains speculative and no other lymphotropic viruses studied to date seem to satisfy the quest for a new candidate virus in young adults with HD. We have recently found preliminary evidence suggesting a possible association between the measles virus (MV) and HD. This evidence is the subject of the present review.

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New Candidate Virus in Association with Hodgkin's Disease

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