Vasculitis Associated with All Trans Retinoic Acid (ATRA) in a Case with Acute Promyelocytic Leukemia

Semra Paydas Department of Oncology, Çukurova University, Faculty of Medicine, Çukurova University Adana, Turkey

Sinan Yavuz Department of Oncology, Çukurova University, Faculty of Medicine, Çukurova University Adana, Turkey

Umut Disel Department of Oncology, Çukurova University, Faculty of Medicine, Çukurova University Adana, Turkey

Berksoy Sahin Department of Oncology, Çukurova University, Faculty of Medicine, Çukurova University Adana, Turkey

Tugba Canbolat Department of Pathology, Çukurova University, Faculty of Medicine, Çukurova University, Adana, Turkey

Ilhan Tuncer Department of Pathology, Çukurova University, Faculty of Medicine, Çukurova University, Adana, Turkey

Abstract

All trans retinoic acid is the drug of choice in the treatment of acute promyelocytic leukemia. But this drug has some side effects, some of which may be life-threatening. Retinoic acid syndrome is the most frequent and dangerous side effect of this differentiation inducing agent. Other side effects include Sweet's syndrome, vasculitis, hypercalcemia, bone marrow necrosis and fibrosis, thromboembolic events, erythema nodosum, granulomatous proliferation and some pulmonary complications. Here, we report vasculitis in a case with APL treated with ATRA and review the literature.

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Vasculitis Associated with All Trans Retinoic Acid (ATRA) in a Case with Acute Promyelocytic Leukemia

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Vasculitis Associated with All Trans Retinoic Acid (ATRA) in a Case with Acute Promyelocytic Leukemia

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