Development of a Transient Monoclonal Gammopathy after Chemotherapy in a Patient with Biphenotypic Acute Leukemia

Roberto Guariglia Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy

Salvatore Guastafierro Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy

Silvana Annunziata Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy

Angelo Tirelli Department of Haematology, Transfusion Medicine and Transplant Immunology, Second University of Naples, Naples, Italy

Abstract

The development of a IgGk monoclonal gammopathy after a phase of bone marrow aplasia following chemotherapy is described in a patient suffering from biphenotypic acute leukemia (BAL). Paraprotein was followed by the relapse of the disease and disappeared during a further chemotherapy. Paraprotein could have been caused by an additional chemotherapy-induced genetic mutation or by a dysfunction in T-B cooperation observed in the phase of reconstitution of the immune system after medullar aplasia.

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Development of a Transient Monoclonal Gammopathy after Chemotherapy in a Patient with Biphenotypic Acute Leukemia

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Development of a Transient Monoclonal Gammopathy after Chemotherapy in a Patient with Biphenotypic Acute Leukemia

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