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Abstract
We have studied the expression of MIB-1 and prognosis in cyclin D1(CyD1) + and CyD1 m mantle cell lymphoma (MCL), and compared them to B-CLL/SLL. All cases were assigned to four groups by immunoreactivity and primary sites: (1) CyD1 + nodal MCL, 11 cases: (2) CyD1 + extranodal MCL (multiple lymphomatous polyposis, (MLP)) three cases: (3) CyD1 m nodal MCL, three cases: and (4) CyD1 m B-CLL/SLL, seven cases. The average of MIB-1 labeling indexes of the four groups were 30.66, 8.70, 9.30 and 4.66, respectively. The CyD1 m group consisting of nodal MCL and CLL/SLL had a significantly longer median survival time (69 months) than the CyD1 + group consisting of nodal MCL and MLP (22 months, P =0.01 ). These data indicate that CyD1 m nodal MCL may show a lower MIB-1 labeling index, and has a better prognosis, than CyD1 + nodal MCL. In addition, a large difference in the average of MIB-1 labeling indexes between nodal MCL and MLP in the CyD1 + group was found.