Prognostic Value of Bcl 10 Rearrangement in Diffuse Large B-cell Lymphoma

C. Kawasaki First Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jyonanku, Fukuoka 814-0180, Japan

K. Ohshima First Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jyonanku, Fukuoka 814-0180, Japan

H. Muta Department of Microbiology and Immunology, University of Miami, Miami, FL, USA

K. Muta The Third Department of Internal Medicine, Kyusyu University, Japan

V. Deyev Department of Microbiology and Immunology, University of Miami, Miami, FL, USA

E.R. Podack Department of Microbiology and Immunology, University of Miami, Miami, FL, USA

M. Kikuchi First Department of Pathology, School of Medicine, Fukuoka University, Nanakuma 7-45-1, Jyonanku, Fukuoka 814-0180, Japan

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Abstract

The role of bcl 10, a recently cloned apoptosis-associated gene, in diffuse large B-cell lymphoma (DLBL) is unknown. Here we determined the role of bcl 10 gene rearrangement on prognosis. Bcl 10 rearrangement was examined by Southern blot. Bcl 10 rearrangement was detected in 20 of 137 (14.6%) samples of DLBL. The frequency of bcl 10 rearrangement was higher in extranodal (eight of 38 cases, 21%) than in nodal (12 of 99, 12%) DLBL. The survival rate in patients with bcl 10 rearrangement tended to be better than in those with germ-line bcl 10, albeit statistically insignificant probably due to the small population sample. The superior prognosis in patients with bcl 10 rearrangement might be due to bcl 10-induced enhanced apoptosis.

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Prognostic Value of Bcl 10 Rearrangement in Diffuse Large B-cell Lymphoma

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Prognostic Value of Bcl 10 Rearrangement in Diffuse Large B-cell Lymphoma

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