Posterior Leukoencephalopathy in Association with the Tumour Lysis Syndrome in Acute Lymphoblastic Leukaemia--A Case with Clinicopathological Correlation

Abstract

We report a case and autopsy findings of posterior leukoencephalopathy (PL) developing during induction chemotherapy for B-cell acute lymphoblastic leukaemia (B-ALL) complicated by tumour lysis syndrome. PL may present with seizures, headache, altered mental status and occipital blindness, associated with transient parieto-occipital abnormalities on neuro-imaging studies. Precipitants include immunosuppressive agents, renal insufficiency, hypertension and fluid retention. It has also been reported in association with pre-eclamptic and eclamptic states, nephrotic syndrome and following liver and bone marrow transplantation. Only rare cases of PL developing during treatment for haematological malignancy have been reported and to our knowledge it has not been previously reported in association with tumour lysis syndrome. Since the condition is generally regarded as being fully reversible few autopsy findings have been reported.

• Tumour Lysis Syndrome
• Posterior Leukoencephalopathy
• Clinico-pathological Correlation
• Acute Lymphoblastic Leukaemia