Two Cases of Adult T-cell Leukemia/Lymphoma Involving the Terminal Ileum

Ken Ohnita Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan

Hajime Isomoto Department of Endoscopy, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan

Takahiro Maeda Department of General Medicine, Nagasaki University School of Medicine, Nagasaki, Japan

Toru Jubashi Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Hideo Nakamura Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Yohei Misuta Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan

Kunihiko Murase Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan

Masao Tomonaga Department of Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

Shigeru Kohno Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan

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Abstract

We describe two cases of adult T-cell leukemia/lymphoma (ATLL) with terminal ileal involvement. The first case, a 71-year-old man with lymphoma subtype of ATLL, had a polypoid lesion in the terminal ileum, in addition to a duodenal mass. The second case, a 58-year-old woman with lymphoma subtype of ATLL, had an irregular ulcerative lesion in the terminal ileum and multiple ulcers throughout the stomach. Biopsies from these lesions revealed mucosal invasion of ATLL cells in each case. In the second case, combination chemotherapy was transiently effective, resulting in the disappearance of gastric and terminal ileal lesions. Prospective and careful examination of additional cases should further characterize the clinicopathological features of terminal ileal involvement in ATLL.

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Two Cases of Adult T-cell Leukemia/Lymphoma Involving the Terminal Ileum

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Two Cases of Adult T-cell Leukemia/Lymphoma Involving the Terminal Ileum

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