Immune Reconstitution Inflammatory Syndrome Mimicking Relapse of AIDS Related Lymphoma in Patients with HIV 1 Infection

T. Powles Departments of Oncology and HIV medicine Chelsea and Westminster Hospital 369 Fulham Road, SWNH 10 9 London UK

C. Thirlwell Departments of Oncology and HIV medicine Chelsea and Westminster Hospital 369 Fulham Road, SWNH 10 9 London UK

M. Nelson Departments of Oncology and HIV medicine Chelsea and Westminster Hospital 369 Fulham Road, SWNH 10 9 London UK

M. Bower Departments of Oncology and HIV medicine Chelsea and Westminster Hospital 369 Fulham Road, SWNH 10 9 London UK

Abstract

People with HIV infection who commence highly active antiretroviral therapy (HAART) occasionally develop reactivation of subclinical infection. This clinical entity is termed immune reconstitution inflammatory syndrome (IRIS) and is defined as a paradoxical deterioration in clinical status as a result of recovery of the immune system during HAART. We present three cases of IRIS following a diagnosis of AIDS related non-Hodgkin's lymphoma that resembled lymphoma relapse.

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Immune Reconstitution Inflammatory Syndrome Mimicking Relapse of AIDS Related Lymphoma in Patients with HIV 1 Infection

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Immune Reconstitution Inflammatory Syndrome Mimicking Relapse of AIDS Related Lymphoma in Patients with HIV 1 Infection

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