Rescue of Interferon Induced Bone Marrow Aplasia in a Patient with Chronic Myeloid Leukemia by Allogeneic Bone Marrow Transplant

A ALABDULAALY Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ont, Canada, M5G 2M9Correspondence[email protected]

J RIFKIND Markham Stouffville Hospital, 381 Church Street, Markham, Ont, Canada, L3P 7P3

H SOLOW Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ont, Canada, M5G 2M9

HA MESSNER Markham Stouffville Hospital, 381 Church Street, Markham, Ont, Canada, L3P 7P3

JH LIPTON Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ont, Canada, M5G 2M9

Abstract

A patient with chronic phase Philadelphia chromosome positive CML, developed severe protracted bone marrow hypoplasia after interferon therapy. This complication did not respond to two courses of immunosuppressive therapy with anti-thymocyte globulin, cyclosporin A and prednisone. The patient continued to be transfusion dependent with persistence of Philadelphia chromosome. Allogeneic BMT restored normal hematopoeisis.

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Rescue of Interferon Induced Bone Marrow Aplasia in a Patient with Chronic Myeloid Leukemia by Allogeneic Bone Marrow Transplant

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Rescue of Interferon Induced Bone Marrow Aplasia in a Patient with Chronic Myeloid Leukemia by Allogeneic Bone Marrow Transplant

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