CD4+ T lymphocyte counts after autologous transplantation in multiple myeloma: A retrospective study

Abstract

The risk for opportunistic infections is correlated with low CD4+ T lymphocyte counts in patients with HIV. We performed a retrospective analysis in 54 patients with multiple myeloma undergoing high-dose melphalan chemotherapy + autologous peripheral blood stem cell transplantation to better define the value of routine control of CD4+ T lymphocyte counts in this important patient group. In 61% of our patients, CD4+ T lymphocyte counts after recovery from neutropenia were <200/µl and <100/µl in 24% (median = 181/µl). Overall survival, progression-free survival, response to antineoplastic therapy and frequency of post-transplant infections were not significantly different when patients with CD4+ T lymphocyte counts <200/µl and >200/µl were compared. However, overall survival was significantly shorter in the subgroup of 13 patients with very low CD4+ T lymphocyte counts (<100/µl) (P = 0.036). In 79.6% of all patients, at least one infection NCI-CTC grade II – IV developed within 100 days post-transplant. Opportunistic infections were rare. This analysis suggests that patients with CD4+ T lymphocyte counts < 100/µl may have a poorer prognosis.

Keywords:

• CD4+ T lymphocytes
• infections
• autologous stem cell transplantation
• multiple myeloma