Composite lymphoma with relapse of enteropathy-type T-cell lymphoma

Zunguo Du Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China

Jieqing Chen Department of Melanoma, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

Xiaoyan Zhou Department of Molecular Pathology, Cancer Center, Fudan University, Shanghai, China

Taiming Zhang Department of Molecular Pathology, Cancer Center, Fudan University, Shanghai, China

Bobin Chen Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China

Feng Tang Department of Pathology, Huashan Hospital, Fudan University, Shanghai, ChinaCorrespondence[email protected]

, MD, PhD

Abstract

We describe an unusual case of with de novo composite diffuse large B-cell lymphoma and enteropathy-type T-cell lymphoma involving the duodenum in a 65-year-old man with celiac disease. A segmental duodenum resection revealed that two neoplastic components had infiltrated the intestinal wall. The coexistence of two malignancies was confirmed by immunohistochemical and molecular biologic analysis, which revealed clonal T-cell receptor γ and immunoglobulin heavy chain gene rearrangements. Epstein–Barr virus was not detected in the B- and T-cell components. After chemotherapy, the patient experienced two relapses of enteropathy-type T-cell lymphoma only. We review the medical literature on composite B- and T-cell lymphomas and discuss their diagnosis, pathogenesis, prognosis and treatment.

Keywords:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Composite lymphoma with relapse of enteropathy-type T-cell lymphoma

Information for

Open access

Opportunities

Help and information

Composite lymphoma with relapse of enteropathy-type T-cell lymphoma

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature