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Increased protein processing gene signature in HDACi-resistant cells predicts response to proteasome inhibitors

Daphné Dupéré-RicherSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Mena KinalSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Filippa PetterssonSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Audrey EmondSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

M. Nieves Calvo-VidalDivision of Hematology and Oncology, Department of Medicine, Cornell University, New York, NY, USA;

Jessica N. NicholSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Cynthia GuilbertSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Dany PlourdeSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Kathleen Klein OrosSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Torsten H. NielsenSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Teresa EzpondaDivision of Hematology/Oncology, Robert. H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

Jonathan D. LichtDivision of Hematology/Oncology, Robert. H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

Nathalie A. JohnsonSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Sarit AssoulineSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada;

Leandro CerchiettiDivision of Hematology and Oncology, Department of Medicine, Cornell University, New York, NY, USA;

Wilson H. Miller Jr.Segal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada; Correspondence[email protected]; [email protected]

Koren K. MannSegal Cancer Center, Lady Davis Institute for Medical Research, McGill University, Montréal, QC, Canada; Correspondence[email protected]; [email protected]

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Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org/10.1080/10428194.2016.1180684.

Funding information

This work was funded by CIHR operating grant [MOP-12863] and the Samuel Waxman Cancer Research Foundation (WHM). The Q-CROC2 clinical trial was financed by Novartis and Roche. DDR is supported by the Cole foundation. LC is the Raymond and Beverly Sackler Scholar and Scholar of the American Society of Hematology. This work was supported by Doris Duke Charitable Foundation Grant [2012070] and the Irma T. Hirschl Career Scientist Award (LC).

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Increased protein processing gene signature in HDACi-resistant cells predicts response to proteasome inhibitors

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