The clinical characteristics and prognostic significance of AID, miR-181b, and miR-155 expression in adult patients with de novo B-cell acute lymphoblastic leukemia

Abstract

This study aimed to investigate clinical characteristics and prognostic significance of activation-induced cytidine deaminase (AID) gene, miR-181b and miR-155 expression in de novo adult B-cell acute lymphoblastic leukemia (B-ALL) patients. Results showed that AID and miR-155 expression were higher in B-ALL patients than healthy controls, while miR-181b expression was lower in B-ALL patients. In addition, Ph⁺ B-ALLs had higher AID expression than Ph^- B-ALLs, and its high expression was associated with BCR-ABL. Moreover, B-ALL patients with AID^high or miR-181b^low expression had a shorter overall survival (OS). AID^high with miR-181b^low, AID^high with miR-155^low, miR-181b^low, miR-155^low, AID^high with miR-181b^low and miR-155^low expression were associated with shorter OS. Combination of the three molecules are more accurate predictors for unfavorable OS compared with univariate group. Therefore, AID, miR-181b and miR-155 provide clinical prognosis of adult de novo B-ALL patients and may refine their molecular risk classification.

Keywords:

• Activation-induced cytidine deaminase
• miR-181b
• miR-155
• B-cell acute lymphoblastic leukemia

Acknowledgments

This work was supported partly by Changzhou Science and Technology Bureau, Jiangsu Province, China (CJ 20130035), Foundation of 333 Project of Jiangsu Province, China (BRA 2015088), National Natural Science Foundation of China (No. 81170513, 81370627).

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at http://dx.doi.org/10.1080/10428194.2017.1283028