MALT1 sequencing analyses in marginal zone B-cell lymphomas reveal mutations in the translocated MALT1 allele in an IGH-MALT1-positive MALT lymphoma

Nuray AkyüzDepartment of Oncology and Hematology with the sections of Bone Marrow Transplantation and Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

Nadine Albert-KonetznyDepartment of Oncology and Hematology with the sections of Bone Marrow Transplantation and Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

Christiane PottDepartment of Medicine II, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrechts University Kiel, Kiel, Germany;

Evelyne Callet-BauchuDepartment of Hematology – Cytogenetic, Groupement Hospitalier Sud, Hospices Civils de Lyon, Lyon, France;

Carsten BokemeyerDepartment of Oncology and Hematology with the sections of Bone Marrow Transplantation and Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

Eva Maria Murga PenasDepartment of Oncology and Hematology with the sections of Bone Marrow Transplantation and Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ;Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrechts University Kiel, Kiel, GermanyCorrespondence[email protected]

Judith DierlammDepartment of Oncology and Hematology with the sections of Bone Marrow Transplantation and Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Correspondence[email protected]

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Acknowledgments

We want to thank Marianne Klokow and Anna Schellenberg for excellent technical assistance.

All patients’ specimens were collected in diagnostic units for haematological malignancies in the context of routine diagnostics and only surplus material was analyzed for the study. Informed consent was obtained from all patients in accordance to local laws approved by the local ethic committees for collecting and archiving their surplus material for further experimental studies in the participating institutes. The study has been performed in accordance with the Helsinki declaration of 1975, as revised in 2000.

This work was supported by the Deutsche Krebshilfe grant 109098 (J.D.).

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at http://dx.doi.org/10.1080/10428194.2017.1296144.

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MALT1 sequencing analyses in marginal zone B-cell lymphomas reveal mutations in the translocated MALT1 allele in an IGH-MALT1-positive MALT lymphoma

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MALT1 sequencing analyses in marginal zone B-cell lymphomas reveal mutations in the translocated MALT1 allele in an IGH-MALT1-positive MALT lymphoma

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