SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia

Abstract

Phosphatase PRL-3 expression is positively associated to acute myeloid leukemia (AML) progression and drug resistance. SH3-domain-binding glutamic acid-rich protein-like protein (SH3BGRL), a downstream effector of PRL-3, plays a tumor suppressive role in solid tumors, but it remains elusive in AML. Here, we followed up and validated the relevance of SH3BGRL expression to AML progression in 116 cases. Results showed that SH3BGRL is down-regulated in 62.37% AML cases with poor prognosis. Cases with positive response to therapy accompanies with SH3GRL expression restoration. Mechanistically, SH3BGRL down-regulation promotes AML cell cycle progression and enhances the anti-apoptotic ability to drug cytotoxicity. While ectopic SH3BGRL blocks AML cell cycle and proliferation to sensitize them to therapeutic drugs via apoptosis. Xenograft assays further confirmed the suppressive role of SH3BGRL in leukemogenesis. Thus, our results demonstrated that SH3BGRL is a novel crucial player in AML progression and could be both a potential diagnostic and prognostic marker.

Keywords:

• Acute myeloid leukemia
• SH3BGRL
• apoptosis
• drug resistance
• cell proliferation

Acknowledgements

We thank our lab members for useful discussion, and Dr. Fahan Haider for critical editing this manuscript.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2017.1344843.

Additional information

Funding

This work was supported by National Science Foundation of China (No. 81672704; 81171947) to WH and Natural Science Foundation of Guangdong (No. 2015A030313090) and Technology Planning Project of Guangdong Province (No. 2017A020215105) to TX. The animal work was supported by Guandong Science and Technology Project (2015B090903063).