Expression of TRIM28 correlates with proliferation and Bortezomib-induced apoptosis in B-cell non-Hodgkin lymphoma

Abstract

Tripartite motif containing 28 (TRIM28) as a transcriptional co-repressor has been reported playing a role in regulating DNA damage response (DDR), cell differentiation, immune response, and tumorigenesis. The present study was performed to explore the biological function and clinical significance of TRIM28 in B-cell non-Hodgkin lymphoma (B-NHL). Results of the study displayed that high expression of TRIM28 was positively associated with the poorer survival of B-NHL patients as an independent prognostic factor. In addition, TRIM28 could promote the B-NHL cells proliferation through modulating cell cycle progression. The change of cyclinA, P21, and PCNA expression after TRIM28 expression modified further illustrated the mechanism in which TRIM28 participated in cell proliferation progression. Moreover, inhibition TRIM28 expression in B-NHL cells enhanced the sensibility to Bortezomib by regulating p53-mediated apoptosis pathway. Taken together, the present study showed that TRIM28 functions as a tumor promoter in B-NHL and may be a novel target for drug resistance to Bortezomib.

Keywords:

• B-cell non-Hodgkin lymphoma (B-NHL)
• TRIM28
• proliferation
• apoptosis
• Bortezomib

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2018.1452207.

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China [No. 81201858, 81373223, 81571616, 81600158], Six Talent Peaks Project in Jiangsu Province [2015-SWYY-021], the Natural Science Foundation of Jiangsu province Grants [BK2012231, BK20131206, BK20160060], the Major Research of Natural Science Foundation for Colleges and Universities in Jiangsu Province [16KJ320004], and Innovative Training Program for Undergraduate in Nantong University, Nantong Science and technology Project [qyz15069, MS22016059, YYZ16026].