Expression of functional folate receptors in multiple myeloma

Ying ZhouDepartment of Medicine, University of Chicago, Chicago, IL, USA;

Kenji UnnoDepartment of Medicine, University of Chicago, Chicago, IL, USA;

Elizabeth HyjekDepartment of Pathology, University of Chicago, IL, USA;

Hui LiuDepartment of Medicine, University of Chicago, Chicago, IL, USA;

Todd ZimmermanDepartment of Medicine, University of Chicago, Chicago, IL, USA;

Subhradip KarmakarDepartment of Medicine, University of Chicago, Chicago, IL, USA;

Karson S. PuttInstitute for Drug Discovery Purdue University, West Lafayette, IN, USA;

Jiayin ShenDepartment of Chemistry, Purdue University, West Lafayette, IN, USA

Philip S. LowInstitute for Drug Discovery Purdue University, West Lafayette, IN, USA; ;Department of Chemistry, Purdue University, West Lafayette, IN, USA

Amittha WickremaDepartment of Medicine, University of Chicago, Chicago, IL, USA; Correspondence[email protected]

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Abstract

Receptor-targeted delivery of imaging and therapeutic agents has emerged as an attractive strategy to diagnosis and treat many diseases including cancer. One of the most well-studied receptors for targeted therapies is the folate receptor (FR) family. FR-α and FR-β are present on many cancers with little expression in normal tissues; leading to the testing of at least six folate-targeted drugs in human clinical trials for various cancers. However, the expression of FR in blood cancers has not been fully explored with no reports of FR expression in myelomas. Herein, we report the expression of both FR-α and FR-β on CD138 + plasma cells isolated from patients with multiple myeloma. In addition, all-trans retinoic acid was shown to increase the levels of FR-α and FR-β in two myeloma cell lines. Altogether, this data suggests that folate-targeted therapies for the treatment of multiple myeloma warrants further investigation.

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Acknowledgements

The work was in part supported by funds from Harith Foundation and Suhith Wickrema Memorial Cancer Fund. We thank Sriram Sundaravel for technical assistance and the personnel in the Flow Cytometry Core facility.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2018.1453066.

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Expression of functional folate receptors in multiple myeloma

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Expression of functional folate receptors in multiple myeloma

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